FAK, phosphorylated (Tyr397) (Focal Adhesion Associated Protein Tyrosine Kinase, BC3)

Supplier:

United States Biological

Cat no: F0019-55G

FAK, phosphorylated (Tyr397) (Focal Adhesion Associated Protein Tyrosine Kinase, BC3)

FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. FAK regulation includes phosphorylation at multiple tyrosine and serine residues. Phosphorylation of tyrosine generally is associated with positive regulation and growth promotion, however, dephosphorylation at these sites occurs as cells enter mitosis (M-Phase of the cell cycle). In contrast, serine phosphorylation either remains high or is increased as cells enter mitosis and may play a role in focal adhesion disassembly. Tyrosine 397 is the autophosphorylation site of Focal Adhesion Kinase. The site binds Src family SH2 domains and the p85 subunit of PI3-Kinase.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nPositive Control:\nLPS treated RAW 264 lysates.\n\nRecommended Dilution:\nWestern Blot: 1:500\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F0019-55G

Size

100ug

Applications

WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in APS, BSA (same/less than) 0.09% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified by ammonium sulfate precipitation.

Isotype

IgG1

Additional Info

Recognizes human Focal Adhesion Kinase (FAK), phosphorylated at (Tyr397). Species Crossreactiviy: mouse.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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