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Fanconi anemia D2 (FA4, FACD, FAD, FAD2, FANCD2, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4)

Fanconi anemia D2 (FA4, FACD, FAD, FAD2, FANCD2, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4)

Cat no: F0019-58W1

Supplier: United States Biological
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Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F0019-58W1
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 100ul
Form: As reported
P type: Mab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
Alternative names: FA4, FACD, FAD, FAD2, FANCD, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4
References: 1. Strahdee, C.A., et al. Evidence for at least four fanconi anaemia genes including FACC on chromosome 9. Nature Genet. 1:196-198, 1992. 2. Timmers, C., et al. Positional cloning of a novel fanconi anemia gene, FANCD2. Molec. Cell. 7:241-248, 2001. (Western Blot, human) 3. Garcia-Higuera, I. et al. Interaction of the fanconi anemia proteins and BRCA1 in a common pathway. Molec. Cell. 7:249-262, 2001. (Western Blot, Immunoprecipitation, human) 4. Nakanishi, K. et al. Interaction of FANCD2 and NBS1 i nthe DNA damage response. Nature Cell Bio. 4:913-920, 2002.
Additional info: This antibody is specific for FANCD2. Species Crossreactivity: Reacts with human FANCD2. Other species have not been tested.

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