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MtoZ Biolabs

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FAS Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250645

FAS Antibody

The FAS antigen (CD95) is a 40-50 kDa cell surface glycoprotein that belongs to the nerve growth factor/tumor necrosis factor (TNF) receptor family. FAS is a receptor for TNFSF6/FASL. The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling comple, Xenopus/Amphibian, (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (asparte-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance in the antigen-stimulated suicide of mature T-cells or both. Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A), a childhood syndrome involving hemolytic anemia and thrombocytopenia.

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SPECIFICATIONS

Catalog Number

250645

Size

0.1 mg

Applications

IHC

Reactivities

Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of rat FAS.

Isotype

Rabbit Ig

Accession

Q63199

Additional Info

FAS; Apo-1; CD95; TNFR superfamily member; FasL receptor; Tumor necrosis factor receptor superfamily member 6; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen

SUPPLIER INFO

ABBIOTEC

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