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FAS Polyclonal Antibody

Cat no: ABP51327

FAS Polyclonal Antibody

Tumor necrosis factor receptor superfamily member 6 encoded by FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

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SPECIFICATIONS

Catalog Number

ABP51327

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IF, IHC-F, WB

Hosts

Rabbit

Reactivities

Hum

Gene Id

355

Isotype

Rabbit IgG

Accession

P25445

Clonality

Polyclonal

Concentration

1 mg/ml

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