FASN (Fatty Acid Synthase)

Supplier:

United States Biological

Cat no: F0020-11B

FASN (Fatty Acid Synthase)

FAS (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis (triglyceride production). It is a target for SREBP and is upregulated by LXR activation. Fatty liver is often the result of FAS activation. It is also one of the accepted markers for insulin resistance and SREBP, LXR activation.\n\nApplications: \nSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000 A band should be seen at ~272kD on SDS-PAGE. May see 1 or 2 minor cross-reacting lower MW bands in liver tissue.\nImmunoprecipitation: 1:100\nImmunohistochemistry: Paraffin\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nMouse liver lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F0020-11B

Size

100ul

Applications

IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Ch/Bird, NHP, Prc

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Dridi S, et al. Am J Physiol Regul Integr Comp Physiol. 2006, 291(1):R138-47. 2. Gao, H., et al. Long-term administration of estradiol decreases expression of hepatic lipogenic genes improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of Stat3. Mol. Endocrinol. 2006. 3. Heemers, H.V., et al. Cancer Res. 2007 67: 3422-3430. 4. Vavere, A. L., et al. J Nucl Med. 2008; 49: 327-334. 5. Bryzgalova G, et al. Am J Physiol Endocrinol Metab. 2008, 295(4):E904-12. 6. Gao H, et al. Mol Endocrinol. 2006; 20(6):1287-99. 7. Basciano H, et al. Am J Physiol Gastrointest Liver Physiol 2009, 297(2):G323-332. 8. Basciano H, et al. Am J Physiol Endocrinol Metab 2009:90764.92008.

Additional Info

Recognizes mouse FASN. Species Crossreactivity: Human, porcine, rat, monkey, chicken, mouse.

Alternative Names

[Acyl-carrier-protein] S-acetyltransferase, [Acyl-carrier-protein] S-malonyltransferase, 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase, 3-oxoacyl-[acyl-carrier-protein] Reductase, 3-oxoacyl-[acyl-carrier-protein] Synthase, Enoyl-[acyl-carrier-protein] Reductase, Oleoyl-[acyl-carrier-protein] Hydrolase

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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