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FASN (Fatty Acid Synthase)

FASN (Fatty Acid Synthase)

Cat no: F0020-11B

Supplier: United States Biological
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FAS (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis (triglyceride production). It is a target for SREBP and is upregulated by LXR activation. Fatty liver is often the result of FAS activation. It is also one of the accepted markers for insulin resistance and SREBP, LXR activation. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 A band should be seen at ~272kD on SDS-PAGE. May see 1 or 2 minor cross-reacting lower MW bands in liver tissue. Immunoprecipitation: 1:100 Immunohistochemistry: Paraffin Optimal dilutions to be determined by the researcher. Positive Control: Mouse liver lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F0020-11B
Reactivities: Human, Mouse, Rat, Chicken/Bird, Non-Human Primate, Porcine
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: [Acyl-carrier-protein] S-acetyltransferase, [Acyl-carrier-protein] S-malonyltransferase, 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase, 3-oxoacyl-[acyl-carrier-protein] Reductase, 3-oxoacyl-[acyl-carrier-protein] Synthase, Enoyl-[acyl-carrier-protein] Reductase, Oleoyl-[acyl-carrier-protein] Hydrolase
References: 1. Dridi S, et al. Am J Physiol Regul Integr Comp Physiol. 2006, 291(1):R138-47. 2. Gao, H., et al. Long-term administration of estradiol decreases expression of hepatic lipogenic genes improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of Stat3. Mol. Endocrinol. 2006. 3. Heemers, H.V., et al. Cancer Res. 2007 67: 3422-3430. 4. Vavere, A. L., et al. J Nucl Med. 2008; 49: 327-334. 5. Bryzgalova G, et al. Am J Physiol Endocrinol Metab. 2008, 295(4):E904-12. 6. Gao H, et al. Mol Endocrinol. 2006; 20(6):1287-99. 7. Basciano H, et al. Am J Physiol Gastrointest Liver Physiol 2009, 297(2):G323-332. 8. Basciano H, et al. Am J Physiol Endocrinol Metab 2009:90764.92008.
Additional info: Recognizes mouse FASN. Species Crossreactivity: Human, porcine, rat, monkey, chicken, mouse.

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