Fatty Acid Binding Protein, Liver (FABP)

Supplier:

United States Biological

Cat no: F0019-76P1

Fatty Acid Binding Protein, Liver (FABP)

The L-FABP protein is derived from the human FABP1 gene. FABPs are small intracellular proteins (~13-14kD) with a high degree of tissue specificity that bind long chain fatty \nacids. They are abundantly present in various cell types and play an important role in the intracellular utilization of fatty acids, transport and metabolism. There are at least nine distinct types of FABP, each showing a specific pattern of tissue expression. Due to its small size, FABP leaks rapidly out of \nischemically damaged necrotic cells leading to a rise in serum levels. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. L-FABP is localized in hepatocytes and brush cells found in the biliary tract, in mucosa of small \nand large intestine and in intestinal metaplasia of the gastric mucosa. Furthermore, L-FABP is present in the epithelium of the proximal tubule of the kidney. \n\nApplications:\nSuitable for use in Western Blot, Immunoprecipitation, Immunofluorescence and Immunohistochemistry. Other applications have not been tested. \n\nRecommended Dilutions:\nWestern Blot: 1:50\nImmunohistochemistry (Frozen, paraffin): 1:50\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F0019-76P1

Size

100ug

Applications

IF, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1. Suzuki, T et al; Immunohistochemical demonstration of liver fatty acid-binding protein in human hepatocellular malignancies. J of Path 1990, 161: 79. 2. Carroll, S et al; Liver fatty acid-binding protein: A marker for studying cellular differentiation in gut epithelial neoplasms. Gastroenterology 1990, 99: 1727.

Additional Info

Recognizes both native and recombinant human liver fatty acid binding protein (L-FABP).

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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