Liver FABP is localized in hepatocytes and brush cells found in the biliary tract. Localization of FABP is demonstrated in mucosa of small and large intestine and in intestinal metaplasia of the gastric mucosa. Fatty acid binding proteins (FABP) are small (~13-14kD) intracellular proteins with a high degree of tissue specificity. FABPs are a class of cytoplasmic proteins that bind long chain fatty acids. They are abundantly present in various cell types and seem to play an important role in the intracellular utilization of fatty acids. There are at least six distinct types of FABP, each showing a specific pattern of tissue expression. FABP leaks due to its small size rapidly out of ischemically damaged dying cells leading to a rise in serum levels. Liver FABP is a sensitive marker for cell damage of liver cells in vitro and in vivo. Ischemically damaged tissues are characterized histological by absence (or low presence) of FABP facilitating recognition of such areas. Next to this L-FABP is a marker for rapid hepatocyte lysis in vitro (as for example in toxicology assays) and for detection of liver damage during and after transplantation.
Applications:
Suitable for use in ELISA, Immunohistochemistry, Western Blot, Purification and Detection of ischemic areas in human liver. Other applications not tested.
Recommended Dilution:
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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