Fe65

Supplier:

United States Biological

Cat no: F0027D

Fe65

Amyloid precursor protein (APP) is a cell-surface protein that is cleaved by g-secretase at the transmembrane region into an extracellular amyloid-beta peptide (Ab) and an intracellular tail fragment. This cytoplasmic tail of APP forms a multimeric complex with the nuclear adaptor protein Fe65 and the histone acetyltransferase Tip60. Fe65 is an adaptor protein that bridges APP to certain molecular pathways. The interaction between APP and Fe65 increases the translocation of APP to the cell surface and the subsequent secretion of Ab. Fe65 is thus important in the regulation and trafficking of APP. Low density lipoprotein receptor-related protein (LRP) also mediates APP processing and is involved with Alzheimer's disease pathogenesis by affecting Ab and APP C-terminal fragment generation. A recent study has shown that Fe65 influences the LRP-mediated effect on APP processing by acting as a functional linker between APP and LRP.\n\nApplications:\nSuitable for use in Immunocytochemistry, Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilutions:\nImmunocytochemistry: Reported to detect Fe65 in rat primary neurons fixed with 4% paraformaldehyde. \nWestern Blot: 1:1000-1:10,000 dilution detects Fe65 in homogenates prepared from whole mouse, rat and human Alzheimer

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SPECIFICATIONS

Catalog Number

F0027D

Size

100ul

Applications

ICC, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, before the addition of glycerol to 30%.

P Type

Mab

Purity

Ascites

Isotype

IgG

References

1. Cao, X., et al., Science 293(5527): 115-120 (2001). 2. Minopoli, G., et al., J. Biol. Chem. 276(9): 6545-6550 (2001). 3. King, G.D., et al., Exp. Neurol. 185(2): 208-219 (2004). 4. Pietrzik, C.U., et al., J. Neurosci. 24(17): 4259-4565 (2004). 5. Sabo, S.L., et al., J. Neurosci. 23: 5407-5415 (2003). 6. Sabo, S.L., et al., J. Cell. Biol. 153: 1403-1414 (2001). 7. Sabo, S.L., et al., J. Biol. Chem. 274: 7952-7957 (1999). 8. Zambrano, N., et al., J. Biol. Chem. 272: 6399-6405 (1997).

Additional Info

Recognizes mouse Fe65, Mr ~97kD. Species Crossreactivity: rat and human

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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