FER (5D2C) Antibody

Cat no: 252725

Supplier: ABBIOTEC

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FER (Fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. FER shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor e, Xenopus/Amphibian,posure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK comple, Xenopus/Amphibian,es containing p85. It is e, Xenopus/Amphibian,pressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be e, Xenopus/Amphibian,pressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.

Catalogue number:	252725
Reactivities:	Human, Mouse
Applications:	Immunofluorescence, Immunohistochemistry
Size:	0.1 ml
Accession:	P16591
Antigen:	Purified recombinant fragment of human FER e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	5D2C4
Additional info:	Tyrosine-protein kinase Fer; Feline encephalitis virus-related kinase; FER; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Proto-oncogene c-Fer; Tyrosine kinase 3; p94-Fer; TYK3;

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FER (5D2C) Antibody

Cat no: 252725

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