Ferritin

Cat no: F4015-04J

Supplier: United States Biological

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Ferritin is important in iron homeostasis. It is the main iron-storage protein, composed of two partially homologous subunits, heavy and light chains. Ferritin molecules in cells containing high levels of iron tend to be rich in light chains, and may have a long-term storage function, whereas heavy-rich ferritins are more active in iron metabolism (1-2). Mutations in the ferritin gene cause the hereditary hyperferritinemia-cataract syndrome and neuroferritinopathy, associated with inflammation. Elevated levels of ferritin are reported as characteristic of adult-onset Still's disease and hemophagocytic syndrome, also associated with inflammation (3). Microfilaments and increased levels of exogenous ferritin are excreted directly into the bile by way of a second microfilament-independent, chloroquine-insensitive pathway, supporting a possible physiological mechanism for the release of ferritin from the liver (4). Applications: Suitable for use in Immunocytochemistry and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000-1:2000 Immunocytochemistry: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

Catalogue number:	F4015-04J
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunocytochemistry, Western Blot
Size:	100ul
Form:	Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
P type:	Mab
Isotype:	IgG
Purity:	Supernatant
References:	1. Boyd D, et al. Proc Natl Acad Sci U S A. 81(15):4751-5, 1984.2. Lawson DM, et al. Nature. 349(6309):541-4, 1991. 3. Zandman-Goddard G, et al. Autoimmunity Reviews 6(7):457-463, 2007 4. Ramm G A, et al. Hepatology 19(2): 504-513, 2005.
Additional info:	Recognizes both heavy and light chains of human Ferritin. Species Crossreactivity: mouse and rat.

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Ferritin

Cat no: F4015-04J

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