FGFR1 (3D4F) Antibody

Cat no: 252899

Supplier: ABBIOTEC

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Description
Additional Information

FGFR1 (Basic fibroblast growth factor receptor 1) is a membrane receptor for basic fibroblast growth factor (FGF2) and for acidic fibroblast growth factor (FGF1). Binding of FGF and heparin leads to receptor dimerization and autophosphorylation at 7 tyrosine residues in the cytoplasmic tail. Phosphorylation of tyrosine 653 and 654 are important for catalytic activity while other sites may provide docking sites for downstream signaling components such as Crk and PLCgamma. FGFR1 also interacts with SHBovine, KLBovine, FGF23, GRB10. FGFR1 activation influences mitogenesis and differentiation of various cell types. Mutations and chromosomal aberrations are associated with various disorders including Pfeiffer Syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, stem cell leukemia lymphoma syndrome and stem cell myeloproliferative disorder.

Catalogue number:	252899
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 ml
Accession:	P11362
Antigen:	Purified recombinant e, Xenopus/Amphibian,tracellular fragment of human FGFR1(aa33-423) fused with hIgGFc tag e, Xenopus/Amphibian,pressed in HEK293 cells.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG2b
Clonality:	3D4F7
Additional info:	FGFR1; Fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; Proto-oncogene c-Fgr; Fms-like tyrosine kinase 2; c-fgr; CD331; FLT-2; FGFBR; FLG; FLT2