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MtoZ Biolabs

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FGFR1 (3D4F) Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 252899

FGFR1 (3D4F) Antibody

FGFR1 (Basic fibroblast growth factor receptor 1) is a membrane receptor for basic fibroblast growth factor (FGF2) and for acidic fibroblast growth factor (FGF1). Binding of FGF and heparin leads to receptor dimerization and autophosphorylation at 7 tyrosine residues in the cytoplasmic tail. Phosphorylation of tyrosine 653 and 654 are important for catalytic activity while other sites may provide docking sites for downstream signaling components such as Crk and PLCgamma. FGFR1 also interacts with SHBovine, KLBovine, FGF23, GRB10. FGFR1 activation influences mitogenesis and differentiation of various cell types. Mutations and chromosomal aberrations are associated with various disorders including Pfeiffer Syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, stem cell leukemia lymphoma syndrome and stem cell myeloproliferative disorder.

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SPECIFICATIONS

Catalog Number

252899

Size

0.1 ml

Applications

WB

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant e, Xenopus/Amphibian,tracellular fragment of human FGFR1(aa33-423) fused with hIgGFc tag e, Xenopus/Amphibian,pressed in HEK293 cells.

Isotype

Mouse IgG2b

Accession

P11362

Clonality

3D4F7

Additional Info

FGFR1; Fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; Proto-oncogene c-Fgr; Fms-like tyrosine kinase 2; c-fgr; CD331; FLT-2; FGFBR; FLG; FLT2

SUPPLIER INFO

ABBIOTEC

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