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FGFR1 Antibody

FGFR1 Antibody

Cat no: 250651

Supplier: ABBIOTEC
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FGFR1 (Basic fibroblast growth factor receptor 1) is a membrane receptor for basic fibroblast growth factor (FGF2) and for acidic fibroblast growth factor (FGF1). Binding of FGF and heparin leads to receptor dimerization and autophosphorylation at 7 tyrosine residues in the cytoplasmic tail. Phosphorylation of tyrosine 653 and 654 are important for catalytic activity while other sites may provide docking sites for downstream signaling components such as Crk and PLCgamma. FGFR1 also interacts with SHBovine, KLBovine, FGF23, GRB10. FGFR1 activation influences mitogenesis and differentiation of various cell types. Mutations and chromosomal aberrations are associated with various disorders including Pfeiffer Syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, stem cell leukemia lymphoma syndrome and stem cell myeloproliferative disorder.
Catalogue number: 250651
Reactivities: Human, Mouse, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P11362
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human FGFR1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: FGFR1; Fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; Proto-oncogene c-Fgr; Fms-like tyrosine kinase 2; c-fgr; CD331; FLT-2; FGFBR; FLG; FLT2
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