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Fibrin Degradation Product, D-Dimer

Fibrin Degradation Product, D-Dimer

Cat no: F4197-15T

Supplier: United States Biological
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D-dimers are the principle degradation products of cross-linked fibrin, released into the bloodstream following the digestion of fibrin clots (thrombus) by the enzyme plasmin, and thus measurement of the level of D-dimer in plasma, can be used as an indication of thrombotic disorders. Conditions in which levels of D-dimer are elevated include deep vein thrombosis (DVT), venous thromboembolism (VTE), cardiovascular disease and disseminated intravascular coagulation (DIC), a possible acute condition arising from surgical operations, septic shock and liver disease. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F4197-15T
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein A affinity chromatography.
References: 1. Rowbotham, B.J. et al. (1987) Measurement of crosslinked fibrin derivatives--use in the diagnosis of venous thrombosis. Thromb. Haemost. 57: 59-61.2. Kruskal, J.B. et al. (1992) Elevated fibrin-related and fibrinogen-related antigens in patients with liver disease. Hepatology. 16: 920-923.
Additional info: Recognizes human D-dimer and high molecular weight fibrin degradation products, but does not crossreact with fibrinogen (D-monomer).

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