Fibrinogen, Human (Coagulation Factor I)

Supplier:

United States Biological

Cat no: F4202-05A

Fibrinogen, Human (Coagulation Factor I)

Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1-16aa) and B (1-17aa) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases.\n\nSource: \nFibrinogen from human plasma.\n\nMolecular Weight: ~340kD\n\nIsoelectric Point: ~5.1-6.3\n\nApplications: \nSuitable for use in ELISA. Other applications not tested\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and freeze at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.

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SPECIFICATIONS

Catalog Number

F4202-05A

Size

2mg

Applications

ELISA

Form

Supplied as a liquid in 10mM sodium citrate, 10mM sodium phosphate, pH 7.3. No preservative added.

Purity

Purified by affinity chromatography.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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