Home  >  Products  >  Fibroblast Activation Protein alpha (FAPa, FAP, 170kD Melanoma Membrane-bound Gelatinase, DKFZP686G13158, DPPIV, EC 3.4.21.-, Integral Membrane Serine Protease, Seprase)
Fibroblast Activation Protein alpha (FAPa, FAP, 170kD Melanoma Membrane-bound Gelatinase, DKFZP686G13158, DPPIV, EC 3.4.21.-, Integral Membrane Serine Protease, Seprase)

Fibroblast Activation Protein alpha (FAPa, FAP, 170kD Melanoma Membrane-bound Gelatinase, DKFZP686G13158, DPPIV, EC 3.4.21.-, Integral Membrane Serine Protease, Seprase)

Cat no: F4208-57G

Supplier: United States Biological
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FAP alpha a type II membrane protein belonging to the serine protease family. FAP alpha is upregulated on activated fibroblasts in response to wounding, and may also be involved in epithelial-mesenchymal interactions during development and tissue repair. Active FAP alpha is a 170kD homodimeric protein which can also exist as a soluble form. FAP alpha can also form heterodimeric complexes with CD26 (DPP4), and these proteins may function co-ordinately to modulate the growth, differentiation, adhesion and metastasis of tumor cells. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 10ug/ml. Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended. Optimal dilutions to be determined by the researcher. Positive Control: Uterus Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F4208-57G
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: 1. Kelly, T. (2005) Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy. Drug Resist. Updat. 8: 51-58.
Additional info: Recognizes human FAP, alpha.

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