Fibroblast Growth Factor Receptor, extracellular domain, Recombinant Human (FGFR, flg5)

Supplier:

United States Biological

Cat no: F4305-15G

Fibroblast Growth Factor Receptor, extracellular domain, Recombinant Human (FGFR, flg5)

Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma (4,5).\n\nSource:\nSf9 \n\nBiological Activity: \nThe human FGF receptor extracellular domain is able to bind radioiodinated basic FGF. In addition, this receptor is able to inhibit basic FGF-mediated proliferation of adrenocortically capillary endothelial cells.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Reconstitute to with sterile dH2O or buffer, aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F4305-15G

Size

10ug

Form

Supplied as a lyophilized powder in PBS, 10mM Tris-HCl, pH 7.0

Purity

Purified by lectin affinity chromatography.

References

1. Kiefer, M.C. et al. (1991) Growth Factors 5:115-127 2. Reid, H.H. et al. (1990) Proc. Natl. Acad. Sci (USA) 87:1596-1600

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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