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FITC anti-mouse CD49d

FITC anti-mouse CD49d

Cat no: 103606

Supplier: BioLegend
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CD49d is a 150 kD glycoprotein, also known as alpha4 integrin or VLA-4 alpha chain. It is a member of the integrin family, expressed on T and B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. CD49d is a heterodimer expressed with either of two beta chains, beta1 (CD29) or beta7, to form the VLA-4 (integrin alpha4beta1) or LPAM-1 (integrin alpha4beta7) complexes. CD49d plays a critical role in both adhesion and T cell costimulation. The primary ligands for CD49d are VCAM-1, MAdCAM-1, and fibronectin. The R1-2 antibody has been shown to partially block CD49d mediated interactions and, in combination with the 9C10(MFR4.B) antibody, completely blocks VCAM-1 binding to VLA-4.
Catalogue number: 103606
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 500 microg
Clone: R1-2
Gene: 16401
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: AKR/Cum mouse spontaneous T lymphoma line TK1
Isotype: Rat IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: alpha4 integrin, VLA-4 alpha chain, integrin a4
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