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FITC anti-NF-kappaB p50

FITC anti-NF-kappaB p50

Cat no: 616706

Supplier: BioLegend
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NF-kappaB/p50 (nuclear factor kappa light chain enhancer in B cells p50, NF-kappaB1) is a member of the Rel/dorsal family. This ubiquitously expressed nuclear protein is one subunit of the NF-kappa B complex consisting of a 65 kD transactivating subunit and a 50 kD DNA binding subunit. Both subunits are derived from larger precursor proteins. NF-kappaB acts as a transcriptional activator and was originally identified as an activator of kappa light chain in B cells. NF-kappaB/p50 is bound (with p65) to IkappaB inhibitor in cytoplasm in inactive form. Phosphorylation of IkappaB releases and NF-kappaB which goes to the nucleus to activate gene expression. NF-kappaB can be activated with LPS, TNF-alpha, phorbol ester, or IL-1. The 4D1 monoclonal antibody reacts with human NF-kappaB p50 and has been shown to be useful for Western blotting.
Catalogue number: 616706
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence
Size: 100 microg
Clone: 4D1
Gene: 4790
Dilutions: For immunofluorescent staining applications, a concentration range of 1-4 microg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: recombinant full-length human NF-kappaB p50
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: NF-kappaB p50, nuclear factor kappa light chain enhancer in B cells p50, NF-kappaB1
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