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FITC anti-rat CD49d

FITC anti-rat CD49d

Cat no: 200103

Supplier: BioLegend
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CD49d is a 150 kD glycoprotein, also known as integrin alpha4 or VLA-4 alpha chain. It is expressed as a heterodimer with either of two beta chains, beta1 or beta7. The alpha4beta1 integrin (also known as VLA-4, CD49d/CD29) is expressed on peripheral T and B lymphocytes, thymocytes, and monocytes, while the alpha4beta7 integrin (also known as LPAM-1) is expressed on peripheral lymphocytes. The alpha4beta1 and alpha4beta7 integrins mediate cell-cell and cell-matrix interactions by interacting with the ligands CD106 (VCAM-1), MAdCAM-1, and fibronectin. Soluble MRalpha4-1 antibody can partially inhibit in vitro binding of VCAM-1 and mast cells to fibronectin and inhibit mast cell degranulation. Immobilized MRalpha4-1 antibody can enhance mast cell degranulation in vitro.
Catalogue number: 200103
Reactivities: Rat
Hosts: Mouse
Applications: Flow Cytometry
Size: 50 microg
Clone: MRalpha4-1
Gene: 16401
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: RBL-2H3 rat basophilic leukemia cell line
Isotype: Mouse IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Integrin alpha4 chain, alpha4 integrin, VLA-4 alpha chain, integrin a4
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