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FK-866 (K 22.175, FK866, APO866, WK175, N-3-(3-pyridinyl)-2E-propenamide)

Cat no: 044815


Supplier: United States Biological
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Nampt/visfatin inhibitor. Inhibitor of NAD+ biosynthesis. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively). Apoptosis inducer. Autophagy inducer. Causes premature senescence. Angiogenesis inhibitor. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 2 years after receipt when stored at -20 degrees C.
Catalogue number: 044815
Size: 1mg
Purity: >98% (NMR)
Alternative names: K 22.175, FK866, APO866, WK175, N--3-(3-pyridinyl)-2E-propenamide
References: Product Reference: ?FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis: M. Hasmann & I. Schemainda; Cancer Res. 63, 7436 (2003) ?NAD depletion by FK866 induces autophagy: R.A. Billington, et al.; Autophagy 4, 385 (2008) ?Extension of human cell lifespan by nicotinamide phosphoribosyltransferase: E. van der Veer, et al.; J. Biol. Chem. 282, 10841 (2007) ?Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma: J. Drevs, et al.; Anticancer Res. 23, 4853 (2003) ?

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