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FK506 Binding Protein 3 (FKBP3, FK506 Binding Protein 25kD, FKBP25)

FK506 Binding Protein 3 (FKBP3, FK506 Binding Protein 25kD, FKBP25)

Cat no: F4150-14D

Supplier: United States Biological
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FK506 binding protein, 25kD molecular weight (FKBP25), also called FKBP3, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues critical for proper folding of proteins. The macrolide immunosuppressant Rapamycin is a potent inhibitor of FKBP25. FKBP25 is localized in the nucleus, where it alters the activity of histone deacetylases and transcription factors. It is found in many tissues, including the brain, thymus, and spleen. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Reconstitute to nominal volume by adding sterile 40-50% glycerol, PBS. Aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F4150-14D
Reactivities: Human, Mouse, Rat
Hosts: Rat
Applications: Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 200ul 40-50% glycerol, PBS.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes human, mouse and rat FKBP25 at 25kD. Does not show cross-reactivity with recombinant human FKBP12, FKBP12.6, FKBP13, FKBP38, FKBP51, or FKBP52.

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