FKHRL1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FKHRL1 is an embryonic transcriptional regulator involved in erythropoiesis and plays an important role in the cell cycle of megakaryocytic cells. It also has a critical role in regulation of proliferation, control of oxidative stress and triggers apoptosis by inducing the expression of genes such as the Fas ligand gene TNFSF6. It is also known to regulate cardiac myocyte size downstream of AKT signaling. FKHRL1 promotes DNA repair under low stress conditions and a program of cell death under higher level of stress thus protecting quiescent cells from oxidative stress.
Applications:
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Western Blot: 2-4ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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