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Flagellin (FliC)

Flagellin (FliC)

Cat no: 044816

Supplier: United States Biological
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Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system. Biological Activity: Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens delivered by subcutaneous and intranasal routes in mice. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 6 months after receipt when stored at -20 degrees C.
Catalogue number: 044816
Size: 10ug
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Purity: >95% (SDS-PAGE)
Alternative names: FliC
References: Product Reference: ?Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity: C. Nempont, et al.; J. Immunol. 181, 2036 (2008) ?
Additional info: Binds to human and mouse TLR5 (Toll-like receptor 5).

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