Supplier:
Alomone Labs Ltd.Cat no: F-140
Flavoxate hydrochloride
The common pharmacological profile of L-type channels is determined by the (A)1 subunit, which forms the Ca2+ selective pore, and is encoded by one of the CaV1 ((A) 1S) channel genes. Cav1.2 (CACNA1C) in humans is widely expressed in cardiac myocytes, smooth muscle myocytes, endocrine cells, neuronal cell bodies and proximal dendrites.
Flavoxate hydrochloride is widely used for the treatment of urinary frequency. Flavoxate increases urinary bladder capacity primarily by suppressing the micturition reflex through modulation of the central nervous system. However, in addition to its activity in the CNS, it possesses direct inhibitory effects on the detrusor muscle. Flavoxate causes a detrusor relaxation through inhibition of L-type Ca+2 (CaV1.2) channels in human urinary bladder detrusor smooth muscle, in a concentration-dependent manner.
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SPECIFICATIONS
Catalog Number
F-140
Size
50 mg
Purity
>96%
Concentration
1-100 uM
Shipping Temp
Room Temperature
Molecular Weight
427.9 Da.
SUPPLIER INFO
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