Fluorescent Human Hepatic Stellate Cells (TFLUOR-HHsteC)

TTFFLUOR Humar Hepatic Stellate Cells (HSteCs) are Green fluorescent primary HSteCs, which has been developed transfecting the tGFP expression vector into the cell genome. These cells are expressing the green fluorescent protein gene sequences as free cytoplasmatic protein. TTFLUOR HSteCs are intended to be used in cell-based assay applications providing consistent levels of tGFP expression during 10-15 doubling populations, the estimated proliferative capacity for these primary cells. HSteC are intralobular connective tissue cells presenting myofibroblast-like or lipocyte phenotypes. They participate in the homeostasis of liver extracellular matrix, repair, regeneration, fibrosis and control retinol metabolism, storage and release. Following liver injury, HSteC transform into myofibroblast-like cells and are the major source of type I collagen in the fibrotic liver. Beyond these feature, HSteC have been implicated as regulators of hepatic microcirculation via cell contraction, and in disease states, in the pathogenesis of intrahepatic portal hypertension. Proliferation and migration of HSteC and expression of chemokines are involved in the pathogenesis of liver inflammation and fibrogenesis. HSteC possess voltage-activated calcium current, express the low affinity nerve growth factor receptor p75, and undergo apoptosis in response to nerve growth factor stimulation. Therefore, the new insight into the molecular regulation of HSteC activation will lead to therapeutic approaches in treatment of hepatic fibrosis in the future, and could lead to reduced morbidity and mortality in patients with chronic liver injury.

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