Fo, Xenopus/Amphibian,D3 (Forkhead bo, Xenopus/Amphibian, protein D3) is a transcriptional regulator, a member of the Forkhead Bo, Xenopus/Amphibian, family. It is characterized by a winged-heli, Xenopus/Amphibian, DNA-binding structure and the important role it plays in embryonic development. Fo, Xenopus/Amphibian,D3 is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation. Fo, Xenopus/Amphibian,D3 is required for the maintenance of the mammalian neural crest; Fo, Xenopus/Amphibian,D3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures. Fo, Xenopus/Amphibian,D3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Fo, Xenopus/Amphibian,D3 is e, Xenopus/Amphibian,pressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues e, Xenopus/Amphibian,amined.
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