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FOXN1 (Forkhead Box Protein N1, Forkhead Box N1, FKHL20, RONU, WHN, Winged-helix Transcription Factor Nude)

FOXN1 (Forkhead Box Protein N1, Forkhead Box N1, FKHL20, RONU, WHN, Winged-helix Transcription Factor Nude)

Cat no: F9048-49A

Supplier: United States Biological
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FOXN1 is a 648aa protein belongs to winged helix:forkhead family containing 1 fork-head DNA-binding domain and is a transcriptional regulator involved in development. It is involved in directing lineage choices of multi-potential progenitor epithelial cells and controls important regulating genes of lympho-epithelial interactions. It modulates keratinocyte differentiation in hair follicle and nail apparatus and its defects leads to T-cell immunodeficiency congenital alopecia, nail dystrophy, macroscopic nudity and an inborn dysgenesis of the thymus. It is expressed in hair follicles, skin and nail apparatus. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:5000 Optimal dilutions to be determined by the researcher. Positive Control: Mouse thymus lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F9048-49A
Reactivities: Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Bleul, CC. et al. Eur. J. Immunol. 31:2497-2503 (2001). 2. Mecklenburg, L. et al. Exp. Dermatol. 14:797-810 (2005). 3. Dooley, J. et al. Dev. Dyn. 233:1605-1612 (2005).
Additional info: Recognizes mouse FOXN1. Species sequence homology: chimpanzee, bovine, human, monkey, rat.

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