FOXN1 (Forkhead Box Protein N1, Forkhead Box N1, FKHL20, RONU, WHN, Winged-helix Transcription Factor Nude)

FOXN1 is a 648aa protein belongs to winged helix:forkhead family containing 1 fork-head DNA-binding domain and is a transcriptional regulator involved in development. It is involved in directing lineage choices of multi-potential progenitor epithelial cells and controls important regulating genes of lympho-epithelial interactions. It modulates keratinocyte differentiation in hair follicle and nail apparatus and its defects leads to T-cell immunodeficiency congenital alopecia, nail dystrophy, macroscopic nudity and an inborn dysgenesis of the thymus. It is expressed in hair follicles, skin and nail apparatus.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000-1:5000\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nMouse thymus lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F9048-49A

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Bleul, CC. et al. Eur. J. Immunol. 31:2497-2503 (2001). 2. Mecklenburg, L. et al. Exp. Dermatol. 14:797-810 (2005). 3. Dooley, J. et al. Dev. Dyn. 233:1605-1612 (2005).

Additional Info

Recognizes mouse FOXN1. Species sequence homology: chimpanzee, bovine, human, monkey, rat.