FOXP1 (Forkhead Box P1, 12CC4, FLJ23741, Forkhead Related Protein-like B, hFKH1B, Glutamine Rich Factor 1, HSPC215, MGC12942, MGC88572, MGC99551, QRF1)

Cat no: F9049-98E

Supplier: United States Biological

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Forkhead box protein 1 (FOXP1) is a member of the Forkhead family of transcription factors, which have been characterized as transcriptional repressors and activators, and as having a DNA-binding domain distinguished by its formation of a winged-helix motif. FOXP1 is known to be an important regulator of airway morphogenesis, lung epithelial development, and early cardiac development. It is also known to have an important role in conjunction with NFkb in the development of B-cells and the differentiation of macrophages. Splice variants give rise to four isoforms of FOXP1. The protein is known to form homodimers and heterodimers with FOXP2 and FOXP4. Studies have indicated FOXP1 as a potential inducer of oncogenesis when over expressed. The depletion and mutation of FOXP1 expression may lead to defects in embryonic cardiac, lung and esophagus epithelial development. Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml Immunocytochemistry: 1:500 Optimal dilutions to be determined by the researcher. Positive Control: Jurkat cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	F9049-98E
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunocytochemistry, Immunohistochemistry, Western Blot
Size:	100ug
Form:	Supplied as a liquid in PBS, 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
P type:	Pab
Purity:	Purified by immunoaffinity chromatography.
Additional info:	Recognizes human FOXP1. Species Crossreactivity: rat, mouse. Species sequence homology: bovine, Rhesus Macaque.

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FOXP1 (Forkhead Box P1, 12CC4, FLJ23741, Forkhead Related Protein-like B, hFKH1B, Glutamine Rich Factor 1, HSPC215, MGC12942, MGC88572, MGC99551, QRF1)

Cat no: F9049-98E

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