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FOXP2, CT (Forkhead Box Protein P2, CAG Repeat Protein 44, Trinucleotide Repeat-containing Gene 10 Protein, CAGH44, TNRC10)

FOXP2, CT (Forkhead Box Protein P2, CAG Repeat Protein 44, Trinucleotide Repeat-containing Gene 10 Protein, CAGH44, TNRC10)

Cat no: F9050-02D

Supplier: United States Biological
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Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4. The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this with this gene plays a role in the modulation neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1.5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human brain (cerebellum) lysates Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F9050-02D
Reactivities: Human, Mouse
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 2001 Oct 4;413(6855):519-23 PMID: 11586359.
Additional info: Recognizes FOXP2. Species Crossreactivity: human and mouse. Species sequence homology: rat, porcine, canine, bovine.

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