FOXP2 (Forkhead Box Protein P2, CAG Repeat Protein 44, CAGH44, DKFZp686H1726, SPCH1, Trinucleotide Repeat-containing Gene 10 Protein, TNRC10)

Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain. The human genome contains 43 Fox proteins that are divided into subfamilies. The FoxP subfamily has four members, FoxP1 to FoxP4, which are broadly expressed and play important roles in organ development, immune response, and cancer pathogenesis. The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region and they contain motifs that promote homo- and heterodimerization. FoxP proteins usually function as transcriptional repressors. FoxP2 regulates lung and nerve system development. Mutations, including point mutation, truncation, deletion, and chromosomal translocation, involving FoxP2 are associated with an inherited form of speech and language disorder.\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degrees C with gentle shaking, overnight.\nImmunoprecipitation: 1:200\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F9050-02C

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, <0.02% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified

Isotype

IgG

References

1. Myatt, S.S. and Lam, E.W. (2007) Nat Rev Cancer 7, 847-59. 2. Shu, W. et al. (2001) J Biol Chem 276, 27488-97. 3. Lu, M.M. et al. (2002) Gene Expr Patterns 2, 223-8. 4. Koon, H.B. et al. (2007) Expert Opin Ther Targets 11, 955-65. 5. Li, S. et al. (2004) Mol Cell Biol 24, 809-22. 6. Shu, W. et al. (2007) Development 134, 1991-2000. 7. Yang, Z. et al. (2010) Life Sci. 8. Konopka, G. et al. (2009) Nature 462, 213-7. 9. Enard, W. et al. (2009) Cell 137, 961-71. 10. Morikawa, Y. et al. (2009) Neuroscience 162, 1150-62. 11. Scharff, C. and White, S.A. (2004) Ann N Y Acad Sci 1016, 325-47. 12. Fisher, S.E. and Scharff, C. (2009) Trends Genet 25, 166-77.

Additional Info

Recognizes endogenous levels of total human FoxP2. \nSpeciesSsequence Homology: mouse and rat