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FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, SCURFIN, XPID)

FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, SCURFIN, XPID)

Cat no: F9050-10R

Supplier: United States Biological
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One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. Several elegant experiments using transgenic mice and retrovirus-mediated over expression studies, have led to the identification of FoxP3, a transcription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FoxP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FoxP3 as a critical palyer in the negative control of various normal and pathological immune responses hold great promise for the development of novel therapies for autoimmune diseases. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F9050-10R
Reactivities: Mouse
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Brunkow,M.E., Jeffery,E.W., Hjerrild,K.A., Paeper,B., Clark,L.B., Yasayko,S.A., Wilkinson,J.E., Galas,D., Ziegler,S.F. and Ramsdell,F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27 (1), 68-73 (2001). 2. Hori,S., Nomura,T. and Sakaguchi,S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (5609), 1057-1061 (2003). 3. Ostroukhova,M., Seguin-Devaux,C., Oriss,T.B., Dixon-McCarthy,B., Yang,L., Ameredes,B.T., Corcoran,T.E. and Ray,A. Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J. Clin. Invest. 114 (1), 28-38 (2004).
Additional info: Recognizes mouse FOXP3. Species sequence homology: canine, human, monkey, rat.

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