FOXP3 (Forkhead Box Protein P3, Scurfin)

FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX); also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.\n\nApplications:\nSuitable for use in ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot\n\nRecommended Dilution:\nOptimal dilutions to be determined by researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

044822

Size

50ug

Applications

ELISA, ICC, IHC, WB

Hosts

Rat

Form

Supplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG2a,k

References

Product Reference: \n?Alternatively activated dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig: Y.Y. Lan, et al.; J. Immunol. 177, 5868 (2006)\n?Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice: M.J. Perone, et al.; J. Immunol. 177, 5278 (2006)\n?Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance: E. Ambrosino, et al.; Cancer Res. 66, 7734 (2006)\n?Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells: G. Raimondi, et al.; J. Immunol. 176, 2808 (2006)\n?Antimetastatic activity of a preventive cancer vaccine: P. Nanni, et al.; Cancer Res. 67, 11037 (2007)\n?Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance: H.R. Turnquist, et al.; J. Immunol. 178, 7018 (2007)\n?Suppression of autoimmune diabetes by soluble galectin-1: M.J. Perone, et al.; J. Immunol. 182, 2641 (2009)\n?

Additional Info

Recognizes mouse FOXP3. Detects a band of ~46-49kD by Western blot.

Alternative Names

Forkhead Box Protein P3, Scurfin