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Fra-2 (Fos Related Antigen 2, FOSL2, FLJ23306)

Cat no: F6045-03A

Fra-2 (Fos Related Antigen 2, FOSL2, FLJ23306)

Fra-2, one of the Fos-related antigens, is promptly expressed after the growth stimulation of fibroblasts, but its induction peak is later than that of c-Fos (1). Fra-2 belongs to the activator protein 1 family of transcription factors, and it regulates the production of extracellular matrix in systemic sclerosis (SSc). It has been demonstrated that Fra-2 is overexpressed in SSc and acts as a novel downstream mediator of the profibrotic effects of TGFb and PDGF. It might be an interesting novel candidate for molecular-targeted therapies for SSc (2).\n\nApplications:\nSuitable for use in Western Blot, Immunoprecipitation and Flow cytometry. Other applications have not been tested. \n\nRecommended Dilutions: \nWestern Blot: 1:1000-1:10,000 \nFlow cytometry: 1:100-1:500 \nImmunoprecipitation: 1:10-1:100\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.\n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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SPECIFICATIONS

Catalog Number

F6045-03A

Size

100ul

Applications

FC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.

P Type

Mab

Purity

Supernatant

References

1. Suzuki T, et al. Nucleic Acids Res 19(20):5537-42, 1991 2. Reich N, et al. Arthritis Rheum 62(1):280-90, 2010

Additional Info

Recognizes human Fra-2. Species crossreactivity: Mouse, rat.

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