Home  >  Products  >  Fractalkine (FKN, A-152E5.2, ABCD-3, Chemokine (C-X3-C Motif) Ligand 1, C-X3-C Motif Chemokine 1, C3Xkine, CXC3, CXC3C, CX3CL1, Neurotactin, NTN, NTT, Small Inducible Cytokine D1, SCYD1)
Fractalkine (FKN, A-152E5.2, ABCD-3, Chemokine (C-X3-C Motif) Ligand 1, C-X3-C Motif Chemokine 1, C3Xkine, CXC3, CXC3C, CX3CL1, Neurotactin, NTN, NTT, Small Inducible Cytokine D1, SCYD1)

Fractalkine (FKN, A-152E5.2, ABCD-3, Chemokine (C-X3-C Motif) Ligand 1, C-X3-C Motif Chemokine 1, C3Xkine, CXC3, CXC3C, CX3CL1, Neurotactin, NTN, NTT, Small Inducible Cytokine D1, SCYD1)

Cat no: F6069-95J

Supplier: United States Biological
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Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1. CX3CL1 is often observed migrating at 80-100kD in SDS-PAGE, presumably due to post- translational modification. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: C2C12 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6069-95J
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Bajetto, A. et al. Front. Neuroendocrinol. 22, 147 (2001). 2. Umehara, H. et al. Immunol. Cell. Biol. 79, 298 (2001). 3. Mizuno, T. et al. Brain Res. 979, 65(2003). 4. Combadiere C. et al. J. Biol. Chem. 273, 23799 (1998).
Additional info: Recognizes human CX3CL1. Species Crossreactivity: mouse.

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