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Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2, Fragile X Mental Retardation Syndrome Related Protein 2, Fragile X Mental Retardation Gene Autosomal Homolog 2, Fragile X Mental Retardation 1-like 2, FMR1L2)

Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2, Fragile X Mental Retardation Syndrome Related Protein 2, Fragile X Mental Retardation Gene Autosomal Homolog 2, Fragile X Mental Retardation 1-like 2, FMR1L2)

Cat no: F6072-30

Supplier: United States Biological
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FXR2 is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. It may self-associate or interact with FMRP and FXR1. Fragile X syndrome is caused by the absence of the fragile X mental-retardation protein (FMRP). FMRP is the archetype of a class of cytoplasmic mRNA-binding proteins that includes the fragile X-related 1 and 2 proteins (FXR1 and FXR2). The fragile X-related proteins FXR1 and FXR2 contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins. Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: Detects a band of approximately 92kD. Optimal dilutions to be determined by the researcher. Localization: Cytoplasmic Gene Symbol: FXR2 Entrez: 9513 (Human) Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F6072-30
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunofluorescence, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2, 15mM.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
References: Zhang Y et al. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. EMBO J 14:5358-66 (1995).
Additional info: Recognizes human FXR2.

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