Home  >  Products  >  Frizzled 10 (FZD10, Frizzled-10, Fz-10, hFz10, FzE7, CD350)
Frizzled 10 (FZD10, Frizzled-10, Fz-10, hFz10, FzE7, CD350)

Frizzled 10 (FZD10, Frizzled-10, Fz-10, hFz10, FzE7, CD350)

Cat no: F6401-45A

Supplier: United States Biological
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FZD10/Frizzled-10 is a 581aa protein belonging to the G-protein coupled receptor Fz/Smo family and containing a signal peptide, a cysteine-rich domain in the N-terminal, seven transmembrane domains and a C-terminal PDZ domain-binding motif. It is involved in transduction, intercellular transmission of polarity information during tissue morphogenesis in differentiated tissues and as a receptor for Wnt proteins. FZD10 is expressed highly in placenta, fetal kidney, fetal lung, brain cerebellum, cerebral cortex, medulla and spinal cord with very low levels in total brain, frontal lobe, temporal lobe, putamen, adult brain, heart, lung and skeletal muscle. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Human brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6401-45A
Reactivities: Human, Mouse, Rat, Non-Human Primate
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Yang, L. et al. J. Dermatol, Sci. 42:111-119 (2006). 2. Zilberberg, A. et al. J. Biol. Chem. 279:17535-17542 (2004).
Additional info: Recognizes human FZD10. Species Crossreactivity: chimpanzee, mouse, monkey, rat. Species sequence homology: bovine and canine.

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