Frizzled 7 (FZD7, Fz-7, hFz7, FzE3, Frizzled-7)

FZD7, a 574aa protein, is a novel member of 'Frizzled' gene family. These proteins act as transmembrane receptors for Wnt signaling proteins. FZD7 contains an N-terminal signaling sequence, a cysteine-rich extracellular domain, 7 putative transmembrane domains and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 participates in cell proliferation through activation of Wnt-beta catenin-TCF pathway. FZD7 gene expression may down-regulate APC function and enhance beta catenin-mediated signals to up-regulate genes associated with cell proliferation in human esophageal carcinomas. Northern Blot analysis detected a ubiquitous expression of FZD7 with high expression in skeletal muscle and fetal kidney.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:100-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

F6401-30D

Size

100ug

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid.

P Type

Pab

Purity

Purified.

Isotype

IgG

References

1. Kirikoshi H et.al Int J Oncol., 19(1):111-5 (2001 Jul). 2. Tanaka et.al PNAS 95 (17); 10164-10169 (August 18, 1998). 3. Sagara N et.al Biochem Biophys Res Commun., 252(1):117-22 (1998 Nov 9).

Additional Info

Recognizes human FZD7. Species Crossreactivity: mouse and rat.