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Frizzled 7 (FZD7, Fz-7, hFz7, FzE3, Frizzled-7)

Frizzled 7 (FZD7, Fz-7, hFz7, FzE3, Frizzled-7)

Cat no: F6401-30D

Supplier: United States Biological
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FZD7, a 574aa protein, is a novel member of 'Frizzled' gene family. These proteins act as transmembrane receptors for Wnt signaling proteins. FZD7 contains an N-terminal signaling sequence, a cysteine-rich extracellular domain, 7 putative transmembrane domains and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 participates in cell proliferation through activation of Wnt-beta catenin-TCF pathway. FZD7 gene expression may down-regulate APC function and enhance beta catenin-mediated signals to up-regulate genes associated with cell proliferation in human esophageal carcinomas. Northern Blot analysis detected a ubiquitous expression of FZD7 with high expression in skeletal muscle and fetal kidney. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6401-30D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid.
P type: Pab
Isotype: IgG
Purity: Purified.
References: 1. Kirikoshi H et.al Int J Oncol., 19(1):111-5 (2001 Jul). 2. Tanaka et.al PNAS 95 (17); 10164-10169 (August 18, 1998). 3. Sagara N et.al Biochem Biophys Res Commun., 252(1):117-22 (1998 Nov 9).
Additional info: Recognizes human FZD7. Species Crossreactivity: mouse and rat.

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