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Fructose-2,6-Biphosphatase 2 (PFKFB2, 6-phosphofructo-2-kinase)

Fructose-2,6-Biphosphatase 2 (PFKFB2, 6-phosphofructo-2-kinase)

Cat no: F8060-01

Supplier: United States Biological
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The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. Applications: Suitable for use in ELISA. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:16,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F8060-01
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: fructose-2,6-bisphosphatase, cardiac isozyme, PFKFB, cardiac, OTTHUMP00000034286, OTTHUMP00000034285, 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, PFK-2/FBPase-2, MGC138310, MGC138308, DKFZp781D2217, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, PFKFB2
References: 1. Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L, A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells. Biochem J. 2008 Apr 1;411(1):41-51.
Additional info: Recognizes Fructose-2,6-Biphosphatase 2. Species sequence homology: human, canine, bovine.

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