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FT(beta) (E285) pAb

FT(beta) (E285) pAb

Cat no: BS3377

Supplier: Bioworld Technology, Inc.
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Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical (alpha) and (beta) subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an (alpha)-(beta) heterodimer. The (beta) subunit binds the peptide substrate while the (alpha) subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate. The (alpha) subunit is shared with a second prenyl transferase, geranyl-geranyl transferase, that attaches 20 carbon geranylgeranyl to Ras related proteins that terminate in a Cys-A-A-Xaa recognition site in which Xaa is leucine.
Catalogue number: BS3377
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P49356
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 250-300 of Human FT(beta).
Species: FT(beta) (E285) pAb detects endogenous levels of FT(beta) protein.
Molecular weight: ~50 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: FNTB; FTase-beta; Protein farnesyltransferase subunit beta;
Additional info: For research use only, not for use in diagnostic procedure.

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