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FTbeta (E285) Peptide

Cat no: BS3377P

FTbeta (E285) Peptide

Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical alpha and beta subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an alpha-beta heterodimer. The beta subunit binds the peptide substrate while the alpha subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate. The alpha subunit is shared with a second prenyl transferase, geranyl-geranyl transferase, that attaches 20 carbon geranylgeranyl to Ras related proteins that terminate in a Cys-A-A-Xaa recognition site in which Xaa is leucine.

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SPECIFICATIONS

Catalog Number

BS3377P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide FTbeta (E285). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P49356

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3377 FTbeta (E285) pAb.

Alternative Names

FNTB; FTase-beta; Protein farnesyltransferase subunit beta;

SUPPLIER INFO

Bioworld Technology, Inc.

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