Supplier:
Alomone Labs Ltd.Cat no: F-120
FTX-3.3
FTX is a polyamine component of the venom of the American funnel web spider Agelenopsis aperta, and has been described as a selective antagonist of P-type voltage-dependent Ca2+ channels. However, it has been demonstrated that FTX has actions at other sites including NMDA and GABA receptors and also on T-type calcium channels.
FTX-3.3 (reputed to be structurally identical to the native FTX) has been synthesized and shown to block P-type calcium channels in rat cerebellar Purkinje cells. It antagonizes P-, N-, and L-type calcium channels in mammalian Purkinje and superior cervical ganglia neurons with similar potencies; Its IC50 against P-, N-, and L-type channels are ~0.13 mM, ~0.24 mM and ~0.24 mM, respectively.
FTX-3.3 does not reduce whole-cell sodium current recorded from SK.N.SH cells and is therefore ion selective.
Alomone Labs is pleased to offer FTX-3.3 (#F-120).
Ion Channel Modulators; Voltage - Gated Ca2+ Channel Blockers.
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SPECIFICATIONS
Catalog Number
F-120
Size
5 x 1 mg
Purity
>99%
Concentration
0.1-1 mM
Shipping Temp
Room Temperature
Molecular Weight
273.4 Da
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