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FUSIP1 (FUS-interacting Protein (Serine-arginine Rich) 1, FUS Interacting Serine Arginine Rich Protein 1, 40kD SR-repressor Protein, FUSIP2, NSSR, OTTHUMP00000015774, Serine Arginine Repressor Protein 40kD, SFRS13, Splicing Factor SRp38, SRp38, SRp40, TLS

Cat no: F9215-50

FUSIP1 (FUS-interacting Protein (Serine-arginine Rich) 1, FUS Interacting Serine Arginine Rich Protein 1, 40kD SR-repressor Protein, FUSIP2, NSSR, OTTHUMP00000015774, Serine Arginine Repressor Protein 40kD, SFRS13, Splicing Factor SRp38, SRp38, SRp40, TLS

FUSIP1 is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. FUSIP1 can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. This antibody is specific for isoform 3 of FUSIP1.\n\nApplications: \nSuitable for use Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5 mg/ml,\nOptimal dilutions to be determined by the researcher.\n\nPositve Control:\nHepG2 whole cell extracts. ~22kDa\n\nStorage and Stability: \nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F9215-50

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in Tris-citrate/phosphate, pH 7-8, 0.01% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human FUSIP1. Species sequence homology: 100% to mouse FUSIP1 isoform 3.

Alternative Names

FUS-interacting Serine-arginine-rich Protein 1

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