Fyn p59 is a membrane-associated non-receptor protein tyrosine kinase that belongs to the Src-family of kinases. The unique N-terminal domain of Fyn p59 interacts with the CD3 and beta chains of the TcR. Fyn p59 can bind with other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of fyn activity. Fyn p59 is highly expressed in brain, suggesting that it may have a role in the sensory nervous network and in myelination at the early stages of CNS formation.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot: 2-4ug/ml for 2h at RT
Optimal dilutions to be determined by the researcher.
Positive Control:
Jurkat cells, lymphoma
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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