G2A belongs to the Lysophospholipid/Lysosphingolipid Receptor family and is an anti-proliferative cell cycle regulator that plays a critical role in controlling peripheral lymphocyte homeostasis. Loss of G2A expression leads to the development of a late-onset autoimmune syndrome (Le et al, 2001). Lysophosphatidylcholine (LPC) is the activating ligand for G2A. G2A is expressed in lymphoid tissues. ESTs have been isolated from normal Human primary B-cell from tonsil, leukocyte, colon, lung, and pancreas/spleen, melanocyte/uterus/fetal heart libraries and from a Human bone marrow cancer library.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 3ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Human spleen
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.