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G Protein Coupled Receptor 15 (GPR15, Brother of Bonzo, BoB, MGC126828, MGC126830)

Cat no: G8600-19G

G Protein Coupled Receptor 15 (GPR15, Brother of Bonzo, BoB, MGC126828, MGC126830)

G protein-coupled receptor GPR15 is an Orphan-A GPCR with an unknown ligand. Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Some HIV-1, HIV-2, and SIV isolates of different genetic subtypes and biological phenotypes use BOB/GPR15 for productive infection, suggesting that this cofactor may play a role in HIV-1 pathogenesis and transmission. GPR15 expression has been reported in CD4(+) T lymphocytes, alveolar macrophages, and the basal surface of the small intestinal epithelium. ESTs have been isolated from normal brain and kidney cancer libraries.\n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 10-20ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman colon, surface epithelium\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G8600-19G

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human GPR15.

Alternative Names

G Protein-coupled Receptor 15, G-protein Coupled Receptor 15

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