Home  >  Products  >  G Protein Coupled Receptor 44 (GPR44, Putative G-protein Coupled Receptor 44, CD294, Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, DL1R, DP2)
G Protein Coupled Receptor 44 (GPR44, Putative G-protein Coupled Receptor 44, CD294, Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, DL1R, DP2)

G Protein Coupled Receptor 44 (GPR44, Putative G-protein Coupled Receptor 44, CD294, Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, DL1R, DP2)

Cat no: G8600-48D

Supplier: United States Biological
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GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 15ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human thymus Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8600-48D
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: G Protein-coupled Receptor 44
Additional info: Recognizes human CRTH2.

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