G Protein Coupled Receptor 68 (GPR68, GPR12A, MGC111379, MGC156983, Ovarian Cancer G-protein Coupled Receptor 1, OGR-1, OGR1, Sphingosylphosphorylcholine Receptor)

OGR1 is a seven pass transmembrane protein initially cloned from an ovarian cancer cell line. OGR1 has a wide expression, and selectively binds both protons and bioactive lipids. OGR1 functions as a proton-sensing G protein-coupled receptor stimulating inositol phosphate production and Ca2+ mobilisation. It is also a receptor for sphingophosphorylcholine and related lysolipids, which antagonise the proton-induced actions mediated by OGR1. OGR1 is also expressed early during osteoclastogenesis and plays a role in osteoclast differentiation.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nImmunohistochemistry (Paraffin): 20ug/ml. Requires antigen retrieval using sodium citrate pH6.0 heat treatment prior to staining of paraffin sections. \nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nTestis\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G8600-72B

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.

P Type

Pab

Purity

Purified by affinity chromatography.

Isotype

IgG

References

1. Mogi, C. et al. (2005) Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. J. Pharmacol. Sci. 99: 160-167.

Additional Info

Recognizes human G Protein Coupled Receptor 68.