Home  >  Products  >  G Protein Coupled Receptor 68 (GPR68, GPR12A, MGC111379, MGC156983, Ovarian Cancer G-protein Coupled Receptor 1, OGR-1, OGR1, Sphingosylphosphorylcholine Receptor)
G Protein Coupled Receptor 68 (GPR68, GPR12A, MGC111379, MGC156983, Ovarian Cancer G-protein Coupled Receptor 1, OGR-1, OGR1, Sphingosylphosphorylcholine Receptor)

G Protein Coupled Receptor 68 (GPR68, GPR12A, MGC111379, MGC156983, Ovarian Cancer G-protein Coupled Receptor 1, OGR-1, OGR1, Sphingosylphosphorylcholine Receptor)

Cat no: G8600-72B

Supplier: United States Biological
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OGR1 is a seven pass transmembrane protein initially cloned from an ovarian cancer cell line. OGR1 has a wide expression, and selectively binds both protons and bioactive lipids. OGR1 functions as a proton-sensing G protein-coupled receptor stimulating inositol phosphate production and Ca2+ mobilisation. It is also a receptor for sphingophosphorylcholine and related lysolipids, which antagonise the proton-induced actions mediated by OGR1. OGR1 is also expressed early during osteoclastogenesis and plays a role in osteoclast differentiation. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 20ug/ml. Requires antigen retrieval using sodium citrate pH6.0 heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Positive Control: Testis Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8600-72B
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: 1. Mogi, C. et al. (2005) Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. J. Pharmacol. Sci. 99: 160-167.
Additional info: Recognizes human G Protein Coupled Receptor 68.

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