OGR1, a Lysophospholipid/Lysosphingolipid Receptor, was isolated by degenerate PCR from an ovarian cell line cDNA library. It is not expressed in normal ovary. OGR1 binds sphingosylphosporylcholine, a lipid molecule involved in cell growth and survival. Recently, OGR1 has been shown to act as a proton-sensing receptor stimulating inositol phosphate formation (Ludwig et al. 2003). OGR1 has been reported to be expressed in blood, brain, heart, kidney, lung, placenta, small intestine, spleen, and testis. ESTs have been isolated from blood, lung, and uterine libraries. Caution: OGR1 is also known as GPR12A, which is distinct from GPR12 in cluster 3851.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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