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G Protein Coupled Receptor 77 (GPCR77, GPR77, C5L2, C5a Anaphylatoxin Chemotactic Receptor)

Cat no: G8600-81C

G Protein Coupled Receptor 77 (GPCR77, GPR77, C5L2, C5a Anaphylatoxin Chemotactic Receptor)

C5L2, also known as GPR77, is a 45kD 7TM receptor that binds the complement proteins \nC3a, C4a, and C5a as well as the acylation stimulating peptide (ASP). C5L2 is expressed on \nvarious hematopoietic cells where it promotes complement-mediated inflammation. ASP \nbinding to C5L2 on adipocytes triggers triglyceride synthesis and glucose uptake and inhibits \nlipolysis. Human C5L2 shares 60% aa sequence identity with mouse and rat C5L2. \n\nApplications: \nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 25ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G8600-81C

Size

100ug

Applications

FC

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2b

Additional Info

Recognizes mouse C5L2.

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