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G Protein Coupled Receptor 77 (GPCR77, GPR77, C5L2, C5a Anaphylatoxin Chemotactic Receptor)

G Protein Coupled Receptor 77 (GPCR77, GPR77, C5L2, C5a Anaphylatoxin Chemotactic Receptor)

Cat no: G8600-81E

Supplier: United States Biological
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C5L2 (C5a receptor-like 2) is a seven-transmembrane orphan receptor, also known as GPR77, which shares significant homology to C5a receptor (CD88). But it is a decoy receptor without G-protein coupling. C5L2 is co-expressed with C5aR on many kinds of cells, such as neutrophils, immature dendritic cells, mast cells, macrophages, and astrocytes. C5L2 binds C5a with similar high affinity as C5aR and relatively higher affinity for C5a-des-Arg than with C5aR. This antibody is known to block C5a binding to C5L2, but does not react with C5a receptor. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)2ug/10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8600-81E
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Scola, AM., et al. 2009. Mol. Immunol. 46:1149. 2. Johswich, K., et al. 2006. J. Bio. Chem. 281:39088. 3. Gerad, NP., et al. 2005. J. Bio. Chem. 280:39677. 4. Okinaga, S., et al. 2003. Biochemistry. 42:9406.
Additional info: Recognizes human C5L2.

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